Article
The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines.
Cancer genetics and cytogenetics - 1 May 2007
Bouker Kerrie B, Skaar Todd C, Harburger David S, Riggins Rebecca B, Fernandez David R, Zwart Alan, Clarke Robert
Abstract excerpt
Loss or mutation of known tumor suppressor genes accounts for a small proportion of all breast cancers. We have recently shown that interferon regulatory factor 1 (IRF1) is a putative tumor suppressor gene in breast cancer. We now report that the A4396G single nucleotide polymorphism in the IRF1 gene is more frequent in human breast cancer cell lines than in the general population (P = 0.01). Furthermore, A4396G...
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