Article
Haplotype of growth hormone and angiotensin I-converting enzyme genes, serum angiotensin I-converting enzyme and ventricular growth: pathway inference in pharmacogenetics.
Pharmacogenetics and genomics - 1 Apr 2007
Huang Shuwen, Chen Xiao-He, Payne John R, Pennell Dudley J, Gohlke Peter, Smith Matt J, Day Ian N M, Montgomery Hugh E, Gaunt Tom R
Abstract excerpt
OBJECTIVES: An insertion/deletion (I/D) polymorphism in the angiotensin I-converting enzyme (ACE) gene is associated with variations in circulating and tissue angiotensin I-converting enzyme activity, and differences in exercise-induced left ventricular hypertrophic response. A genetic marker (CSH1.01) in the syntenic GH-CSH gene cluster correlates with metabolic syndrome in adult life in males. Approximately 24%...
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