Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Building individualized medicine: prevention of adverse reactions to warfarin therapy.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2007

Krynetskiy Evgeny, McDonnell Patrick

Abstract excerpt

Warfarin is the most widely used oral anticoagulant in the world for patients with venous thrombosis, pulmonary embolism, chronic atrial fibrillation, and prosthetic heart valves. Approximately 30 genes contribute to therapeutic effects of warfarin, and genetic polymorphisms in these genes may modulate its anticoagulant activity. In contrast to monogenic pharmacogenetic traits, warfarin drug response is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbon-Carbon Ligases
Share to Cytochrome P-450 CYP2C9
Share to Drug-Related Side Effects and Adverse Reactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epoxide Hydrolases

Share to Orosomucoid

Share to Protein C

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Identifiers

PMID: 17496169
DOI: 10.1124/jpet.106.117952

Genes

VKORC1
EPHX1
GGCX
ORM1
PROC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Building individualized medicine: prevention of adverse reactions to warfarin therapy.PMID 17496169Read ↗

The pharmocogenomics of warfarin: closing in on personalized medicine.Semantic proximity Read ↗

Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues.Semantic proximity Read ↗

A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity.Semantic proximity Read ↗

Pharmacogenetic determinants of warfarin in the Indian population.Semantic proximity Read ↗

Clinical pharmacogenomics and concept of personalized medicine / Klinička farmakogenomika i koncept personalizovane medicineSemantic proximity Read ↗

Clinical Review of the Pharmacogenomics of Direct Oral Anticoagulants.Semantic proximity Read ↗

Is personalized medicine a dream or a reality?Semantic proximity Read ↗

Pharmacogenetics of warfarin: challenges and opportunitiesSemantic proximity Read ↗

Pharmacogenetics of warfarin: current status and future challenges.Semantic proximity Read ↗

Pharmacogenomics of warfarin: uncovering a piece of the warfarin mystery.Semantic proximity Read ↗

Being precise with anticoagulation to reduce adverse drug reactions: are we there yet?Semantic proximity Read ↗

Recent developments and future directions for the use of pharmacogenomics in cardiovascular disease treatments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.