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Article

Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy White population.

Diabetic medicine : a journal of the British Diabetic Association - 1 Aug 2007

Staiger H, Machicao F, Machann J, Schick F, Kuulasmaa T, Laakso M, Fritsche A, Stefan N, Häring H-U

Abstract excerpt

AIMS: APPL1 (adaptor protein containing PH domain, PTB domain and leucine zipper motif 1) is the first identified cytosolic protein that directly binds to adiponectin receptors and mediates cellular responses to adiponectin. We set out to determine whether genetic variation within the APPL locus (encoding APPL1) contributes to insulin resistance, changes in lipid metabolism or inflammatory parameters in a healthy...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17490420
DOI: 10.1111/j.1464-5491.2007.02166.x

Genes

APPL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy White population.PMID 17490420Read ↗

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