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Article

The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.

Journal of cell science - 1 Jun 2007

Berto Gaia, Camera Paola, Fusco Carlo, Imarisio Sara, Ambrogio Chiara, Chiarle Roberto, Silengo Lorenzo, Di Cunto Ferdinando

Abstract excerpt

The Down syndrome critical region (DSCR) on Chromosome 21 contains many genes whose duplication may lead to the major phenotypic features of Down syndrome and especially the associated mental retardation. However, the functions of DSCR genes are mostly unknown and their possible involvement in key brain developmental events still largely unexplored. In this report we show that the protein TTC3, encoded by one of...

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Source

Identifiers

PMID: 17488780
DOI: 10.1242/jcs.000703

Genes

CIT
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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