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Article

Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2011

Susser Simone, Vermehren Johannes, Forestier Nicole, Welker Martin Walter, Grigorian Natalia, Füller Caterina, Perner Dany, Zeuzem Stefan, Sarrazin Christoph

Abstract excerpt

BACKGROUND: Telaprevir and boceprevir are highly selective hepatitis C virus (HCV) NS3/4A proteaseinhibitors in phase 3 development. Viral breakthrough during mono- and triple-therapies with PEG-interferon and ribavirin and relapse is associated with resistance. OBJECTIVES: Potential persistence of resistance mutations during long-term follow-up should be analyzed. STUDY DESIGN: Clonal sequence analysis of the...

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Source

Identifiers

PMID: 21924672
DOI: 10.1016/j.jcv.2011.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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