Article
Rapid detection of alpha + thalassaemia deletion & alpha-globin gene triplication by Gap-PCR in Indian subjects.
The Indian journal of medical research - 1 Oct 2002
Agarwal Sarita, Sarwai Swati, Nigam Nitu, Singhal Pragya
Abstract excerpt
BACKGROUND & OBJECTIVES: Southern blot hybridization is the commonly used method to delineate alpha globin gene defects. This technique is time consuming, requires a large amount of genomic DNA and radioactive probes for detecting the mutations, which limits its use in diagnosis. The present paper emphasizes the efficacy of a well-established Gap-PCR technique in the Indian set up to detect defects of the alpha...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.