Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1

14 Nov 2006

Abstract excerpt

To molecularly define high-risk disease, we performed microarray analysis on tumor cells from 532 newly diagnosed patients with multiple myeloma (MM) treated on 2 separate protocols. Using log-rank tests of expression quartiles, 70 genes, 30% mapping to chromosome 1 (P < .001), were linked to early disease-related death. Importantly, most up-regulated genes mapped to chromosome 1q, and down-regulated genes mapped...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Multiple Myeloma Research and Treatments
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17105813
DOI: 10.1182/blood-2006-07-038430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1PMID 17105813Read ↗

Gene expression profiling defines a high-risk entity of multiple myeloma.Semantic proximity Read ↗

High-risk disease in newly diagnosed multiple myeloma: beyond the R-ISS and IMWG definitionsSemantic proximity Read ↗

Gene Expression Profiling in Multiple Myeloma: Redefining the Paradigm of Risk-Adapted TreatmentSemantic proximity Read ↗

Prediction of high- and low-risk multiple myeloma based on gene expression and the International Staging SystemSemantic proximity Read ↗

Gene Expression Profiling in Multiple Myeloma—Reporting of Entities, Risk, and Targets in Clinical RoutineSemantic proximity Read ↗

A gene expression signature based on cell-death related gene expression in multiple myelomaSemantic proximity Read ↗

High WEE1 expression is independently linked to poor survival in multiple myelomaSemantic proximity Read ↗

Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cellsSemantic proximity Read ↗

Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patientsSemantic proximity Read ↗

High-Risk Multiple Myeloma: Redefining Risk and Rethinking Therapy.Semantic proximity Read ↗

Transcriptional features of multiple myeloma patients with chromosome 1q gainSemantic proximity Read ↗

Translating a gene expression signature for multiple myeloma prognosis into a robust high-throughput assay for clinical useSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.