Article
Mannose-binding lectin gene polymorphisms in a cohort study of ANCA-associated small vessel vasculitis.
Rheumatology (Oxford, England) - 1 Jul 2007
Kamesh L, Heward J M, Williams J M, Gough S C L, Savage C O S, Harper L
Abstract excerpt
OBJECTIVE: To investigate whether single nucleotide polymorphisms (SNPs) within the mannose-binding lectin (MBL) gene are associated with small vessel vasculitis (SVV) and are a risk factor for intercurrent infection, as described previously in other autoimmune diseases. METHODS: Six SNPs in the MBL promoter and coding region were genotyped by sequence-specific polymerase chain reaction or restriction fragment...
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