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Article

Epigenetic regulation of motor neuron cell death through DNA methylation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Nov 2011

Chestnut Barry A, Chang Qing, Price Ann, Lesuisse Catherine, Wong Margaret, Martin Lee J

Abstract excerpt

DNA methylation is an epigenetic mechanism for gene silencing engaged by DNA methyltransferase (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene-regulatory regions. It is unknown whether aberrant DNA methylation can cause neurodegeneration. We tested the hypothesis that Dnmts can mediate neuronal cell death. Enforced expression of Dnmt3a induced degeneration of cultured NSC34 cells. During...

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Identifiers

PMID: 22090490
DOI: 10.1523/JNEUROSCI.1639-11.2011
PMCID: PMC3238138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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