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Article

Rapid alpha-1-antitrypsin M-variant genotyping by primer-induced restriction analysis.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 2007

Yajloo Mohsen Mohammadian, Lotfi Abbas Sahebghadam, Mesbah Namin Seyed Alireza, Hasannia Sadegh, Biglarzadeh Maryam, Ardalan Arman

Abstract excerpt

The 4 normal alleles of M1, M2, M3, and M4 are the most common gene products of the human alpha-1-antitrypsin (hAAT). Two single substitutions in M1 are responsible for M3 and M4, whereas 2 substitutions in M1 produce M2. Polymerase chain reaction-restriction fragment length polymorphism analysis of the Arg(101)/His(101) sequence variation can separate M1 and M3 from M2 and M4 alleles. To complete the genotyping...

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PMID: 17471159
DOI: 10.1097/01.pdm.0000213465.06387.7f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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