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Article

Synthetic biology of phenotypic adaptation in vertebrates: the next frontier.

Molecular biology and evolution - 1 Jul 2013

Yokoyama Shozo

Abstract excerpt

For over the last 2 decades, positively selected amino acid sites have been inferred almost exclusively by showing that the number of nonsynonymous substitutions per nonsynonymous site (dn) is greater than that of synonymous substitutions per synonymous site (ds). However, virtually none of these statistical results have been experimentally tested and remain as hypotheses. To perform such experimental tests, we...

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Identifiers

PMID: 23603936
DOI: 10.1093/molbev/mst075
PMCID: PMC3684858

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