Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for epistatic interaction between VDR and SLC13A2 genes in the pathogenesis of hypocitraturia in recurrent calcium oxalate stone formers.

Journal of nephrology - 1 Jun 2017

Rendina Domenico, De Filippo Gianpaolo, Gianfrancesco Fernando, Muscariello Riccardo, Schiano di Cola Michele, Strazzullo Pasquale, Esposito Teresa

Abstract excerpt

BACKGROUND: Genetic factors play a key role in the pathogenesis of hypocitraturia, a common risk factor for nephrolithiasis. The Na+-dicarboxylate cotransporter NaDC1, encoded by the sodium-dicarboxylate cotransporter (SLC13A2) gene, is a major determinant of urinary citrate excretion and its biological functions are regulated also by the vitamin D/Vitamin D receptor (VDR) biological system. The aim of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chi-Square Distribution
Share to Citric Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Nephrolithiasis

Share to Organic Anion Transporters, Sodium-Dependent

Share to Receptors, Calcitriol

Share to Recurrence

Share to Symporters

Source

Identifiers

PMID: 27639591
DOI: 10.1007/s40620-016-0348-8

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for epistatic interaction between VDR and SLC13A2 genes in the pathogenesis of hypocitraturia in recurrent calcium oxalate stone formers.PMID 27639591Read ↗

Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls.Semantic proximity Read ↗

rs11567842 SNP in SLC13A2 gene associates with hypocitraturia in Thai patients with nephrolithiasis.Semantic proximity Read ↗

Genetics of kidney stone disease-Polygenic meets monogenic.Semantic proximity Read ↗

Association between vitamin D receptor gene polymorphisms and tubular citrate handling in calcium nephrolithiasis.Semantic proximity Read ↗

Progress in Understanding the Genetics of Calcium-Containing NephrolithiasisSemantic proximity Read ↗

Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis.Semantic proximity Read ↗

Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout.Semantic proximity Read ↗

Association of single nucleotide genetic polymorphisms of vitamin D receptor and calcium-sensitive receptor with calcium-containing kidney stones in Chinese Dai populations: a prospective multi-center study.Semantic proximity Read ↗

Genetic determinants of urolithiasis.Semantic proximity Read ↗

The relationship of 3' vitamin D receptor haplotypes to urinary supersaturation of calcium oxalate salts and to age at onset and familial prevalence of nephrolithiasis.Semantic proximity Read ↗

Idiopathic calcium nephrolithiasis: a review of pathogenic mechanisms in the light of genetic studies.Semantic proximity Read ↗

Association between vitamin D receptor gene polymorphisms and idiopathic hypocitraturia in a Chinese Bai population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.