Article
Diffuse sclerosing variant of papillary thyroid carcinoma: lack of BRAF mutation but occurrence of RET/PTC rearrangements.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2007
Sheu Sien-Yi, Schwertheim Suzan, Worm Karl, Grabellus Florian, Schmid Kurt Werner
Abstract excerpt
Diffuse sclerosing variant of papillary thyroid carcinoma (PTC) is a rare tumour with a characteristic morphology as well as a strong preponderance for younger female patients. The T1799A missense mutation in exon 15 of the BRAF gene and RET/PTC rearrangement have been identified as the dominant genetic tumour initiation events in the pathogenesis of PTC leading to a constitutive activation of the RAS-RAF-MAPK...
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