Article
Proteins encoded by the conservon of Streptomyces coelicolor A3(2) comprise a membrane-associated heterocomplex that resembles eukaryotic G protein-coupled regulatory system.
Molecular microbiology - 1 Dec 2006
Komatsu Mamoru, Takano Hideaki, Hiratsuka Tomonari, Ishigaki Yuji, Shimada Kyoko, Beppu Teruhiko, Ueda Kenji
Abstract excerpt
Streptomyces coelicolor A3(2) retains unique conserved operons termed conservons. Here, one of the conservons (cvn9), which encodes five proteins (A9-E9), was characterized. Mutants for cvnA9 and cvnAlO conditionally overproduced actinorhodin and performed precocious aerial growth, while a cvnE9 mutant showed the parental phenotype. Transcription of bidG, adpA and bldN was upregulated in the cvnA9 mutant. A9-D9...
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