Identification of a new HLA-B allele (B*1576) by haplotype specific extraction.

doi:10.1016/j.humimm.2007.01.015

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Identification of a new HLA-B allele (B*1576) by haplotype specific extraction.

Human immunology - 1 May 2007

Dapprich Johannes, Witter Klaus, Gabel Harrison W, Murphy Nancy B, Albert Ekkehard D

Abstract excerpt

Routine typing of a potential bone marrow donor by sequence-specific oligonucleotide probes (SSOP) and sequence based typing (SBT) produced inconclusive subtyping results, suggesting a new allele. A magnetic bead-based method, haplotype specific extraction (HSE), was used to separate the diploid sample into its haploid components. The sample was then re-typed using standard SBT, revealing a new human leukocyte...

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Identification of a new HLA-B allele (B*1576) by haplotype specific extraction.

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