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Article

Isoniazid induces its own resistance in nonreplicating Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Jun 2007

Siddiqi Salman, Takhar Param, Baldeviano Christian, Glover William, Zhang Ying

Abstract excerpt

Isoniazid (INH) resistance is most frequent among drug-resistant Mycobacterium tuberculosis clinical isolates. This study was conducted to investigate whether INH could induce its own resistance. During INH susceptibility testing in BACTEC 12B and MGIT 960 media, weekly subcultures were made from the drug-containing media into fresh medium without drug and susceptibility testing was performed. Rifampin (RIF) was...

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Identifiers

PMID: 17438054
DOI: 10.1128/AAC.00086-07
PMCID: PMC1891357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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