Article
Pre-clinical and clinical evaluation of estramustine, docetaxel and thalidomide combination in androgen-independent prostate cancer.
BJU international - 1 May 2007
Figg William D, Li Haiqing, Sissung Tristan, Retter Avi, Wu Shenhong, Gulley James L, Arlen Phil, Wright John J, Parnes Howard, Fedenko Kathy, Latham Lea, Steinberg Seth M, Jones Elizabeth, Chen Clara, Dahut William
Abstract excerpt
OBJECTIVE: To evaluate the combination of docetaxel plus estramustine (which prolongs survival in patients with androgen-independent prostate cancer, AIPC), and thalidomide (that also adds to docetaxel activity), both pre-clinically and clinically in AIPC. PATIENTS, MATERIALS AND METHODS: In the pre-clinical evaluation we injected PC3 cells subcutaneously into severely combined immunodeficient mice and started...
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