Article
CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis.
American journal of human genetics - 1 May 2007
Gao Xiaochong, Gordon Derek, Zhang Dongping, Browne Richard, Helms Cynthia, Gillum Joseph, Weber Samuel, Devroy Shonn, Swaney Saralove, Dobbs Matthew, Morcuende Jose, Sheffield Val, Lovett Michael, Bowcock Anne, Herring John, Wise Carol
Abstract excerpt
Idiopathic scoliosis (IS) is the most common spinal deformity in children, and its etiology is unknown. To refine the search for genes underlying IS susceptibility, we ascertained a new cohort of 52 families and conducted a follow-up study of genomewide scans that produced evidence of linkage and association with 8q12 loci (multipoint LOD 2.77; P=.0028). Further fine mapping in the region revealed significant...
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