Article
Senescent phenotypes of skin fibroblasts from patients with Tangier disease.
Biochemical and biophysical research communications - 1 Jun 2007
Matsuura Fumihiko, Hirano Ken-Ichi, Ikegami Chiaki, Sandoval Jose C, Oku Hiroyuki, Yuasa-Kawase Miyako, Tsubakio-Yamamoto Kazumi, Koseki Masahiro, Masuda Daisaku, Tsujii Ken-Ichi, Ishigami Masato, Nishida Makoto, Shimomura Iichiro, Hori Masatsugu, Yamashita Shizuya
Abstract excerpt
Tangier disease (TD) is characterized by a deficiency of high density lipoprotein (HDL) in plasma and patients with TD have an increased risk for coronary artery disease (CAD). Recently, we reported that fibroblasts from TD exhibited large and flattened morphology, which is often observed in senescent cells. On the other hand, data have accumulated to show the relationship between cellular senescence and...
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