Growth and molecular evolution of vesicular stomatitis serotype New Jersey in cells derived from its natural insect-host: evidence for natural adaptation.

doi:10.1016/s0168-1702(02)00113-2

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Article

Growth and molecular evolution of vesicular stomatitis serotype New Jersey in cells derived from its natural insect-host: evidence for natural adaptation.

Virus research - 1 Oct 2002

Llewellyn Z N, Salman M D, Pauszek S, Rodriguez Luis L

Abstract excerpt

In this study we evaluated the growth and molecular evolution of a natural isolate of VSV-NJ (89GAS) from sand flies in cells derived from sand flies (LL5), mosquitoes (C6/36) or hamsters (BHK21). Two VSV-NJ natural isolates of mammalian origin were used for comparison. For each virus we measured: (i) ability to grow in one-step growth curve or after serial passage on each cell type; (ii) ability to induce...

Topics

Adaptation, Physiological
Animals
Cell Line
Cricetinae
Culicidae
Evolution, Molecular
Membrane Glycoproteins
Mutation
Psychodidae
Sequence Analysis, DNA
Serial Passage
Vesiculovirus
Viral Envelope Proteins

Source

Open in PubMed

Identifiers

PMID: 12367751
DOI: 10.1016/s0168-1702(02)00113-2

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