Article
Epithelial barrier disruption allows nondisease-causing bacteria to initiate and sustain IBD in the IL-10 gene-deficient mouse.
Inflammatory bowel diseases - 1 Aug 2007
Sydora Beate C, Macfarlane Sarah M, Walker John W, Dmytrash Andrea L, Churchill Thomas A, Doyle Jason, Fedorak Richard N
Abstract excerpt
BACKGROUND: In the IL-10 gene-deficient mouse model, development of intestinal inflammation is associated with a defect in epithelial barrier integrity that is thought to allow sufficient passage of bacteria or bacterial antigens to initiate a mucosal immune response. Microbial monoassociation experiments into axenic animals have shown that some, but not all, endogenous bacteria will initiate an intestinal...
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