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Article

Polycomb Repressive Complex 2 Silences Human Cytomegalovirus Transcription in Quiescent Infection Models

26 Sept 2013

Abstract excerpt

Chromatin-based regulation of herpesviral transcriptional programs is increasingly appreciated as a mechanism for modulating infection outcomes. Transcriptionally permissive euchromatin predominates during lytic infection, whereas heterochromatin domains refractory to transcription are enriched at lytic genes during latency. Reversibly silenced facultative heterochromatin domains are often enriched for histone H3...

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PMID: 24067968
DOI: 10.1128/jvi.02420-13

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