Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Large granular lymphocyte proliferation and revertant mosaicism: two rare events in a Wiskott-Aldrich syndrome patient.

Haematologica - 1 Mar 2007

Boztug Kaan, Baumann Ulrich, Ballmaier Matthias, Webster David, Sandrock Inga, Jacobs Roland, Lion Thomas, Preuner Sandra, Germeshausen Manuela, Hansen Gesine, Welte Karl, Klein Christoph

Abstract excerpt

We report on a 6 year old patient with an unusual clinical presentation of WAS and oligoclonal proliferation of TCR+ large granular lymphocytes (LGL). Flow cytometry demonstrated two distinct populations of lymphocytes with strongly decreased (WASP-) or normal expression levels of WASP (WASP+), respectively. Molecular analysis confirmed a splice site mutation in intron 2 of the WASP gene in the WASP- cells but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Haemophilus Infections
Share to Lymphoproliferative Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Purpura, Thrombocytopenic, Idiopathic

Share to Receptors, Antigen, T-Cell, gamma-delta

Share to RNA Splice Sites

Share to T-Lymphocyte Subsets

Share to Wiskott-Aldrich Syndrome

Share to Wiskott-Aldrich Syndrome Protein

Source

Identifiers

PMID: 17405757
DOI: 10.3324/haematol.11222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Large granular lymphocyte proliferation and revertant mosaicism: two rare events in a Wiskott-Aldrich syndrome patient.PMID 17405757Read ↗

Somatic mosaicism in the Wiskott-Aldrich syndrome: molecular and functional characterization of genotypic revertants.Semantic proximity Read ↗

Multiple independent second‐site mutations in two siblings with somatic mosaicism for Wiskott–Aldrich syndromeSemantic proximity Read ↗

Unprecedented diversity of genotypic revertants in lymphocytes of a patient with Wiskott-Aldrich syndrome.Semantic proximity Read ↗

Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: analysis of function and distribution in lymphoid organs.Semantic proximity Read ↗

CLINICAL FEATURES AND GENETIC ANALYSIS OF SIX PATIENTS WITH WISKOTT-ALDRICH SYNDROME REPORTING TWO NOVEL MUTATIONS: EXPERIENCE OF ERCIYES UNIVERSITY, KAYSERI, TURKEY.Semantic proximity Read ↗

Revertant somatic mosaicism in the Wiskott-Aldrich syndrome.Semantic proximity Read ↗

Spontaneous in vivo reversion of an inherited mutation in the Wiskott-Aldrich syndrome.Semantic proximity Read ↗

Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings.Semantic proximity Read ↗

Molecular and phenotypic abnormalities of B lymphocytes in patients with Wiskott-Aldrich syndromeSemantic proximity Read ↗

Detection of lymphocytes and granulocytes expressing the mutant WASP message in carriers of Wiskott-Aldrich syndrome.Semantic proximity Read ↗

Wiskott–Aldrich syndrome presenting with a clinical picture mimicking juvenile myelomonocytic leukaemiaSemantic proximity Read ↗

Two novel mutations identified in the Wiskott-Aldrich syndrome protein gene cause Wiskott-Aldrich syndrome and thrombocytopenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.