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Article

Molecular mechanism of arachidonic acid inhibition of the CFTR chloride channel.

European journal of pharmacology - 1 Jun 2007

Zhou Jing-Jun, Linsdell Paul

Abstract excerpt

Arachidonic acid inhibits the activity of a number of different Cl- channels, however its molecular mechanism of action is not known. Here we show that inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels by arachidonic acid is weakened following mutagenesis of two positively charged pore-lining amino acids. Charge-neutralizing mutants K95Q and R303Q both increased the Kd for...

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Source

Identifiers

PMID: 17397825
DOI: 10.1016/j.ejphar.2007.02.048

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular mechanism of arachidonic acid inhibition of the CFTR chloride channel.PMID 17397825Read ↗

Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore.Semantic proximity Read ↗

Cystic fibrosis gene mutation (deltaF508) is associated with an intrinsic abnormality in Ca2+-induced arachidonic acid release by epithelial cells.Semantic proximity Read ↗

Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge.Semantic proximity Read ↗

Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance.Semantic proximity Read ↗

Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore.Semantic proximity Read ↗

Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors.Semantic proximity Read ↗

Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy.Semantic proximity Read ↗

CFTR Modulators: From Mechanism to Targeted Therapeutics.Semantic proximity Read ↗

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