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Article

HLA Class I–Restricted T Cell Epitopes of the Kinetoplastid Membrane Protein–11 Presented by<i>Leishmania donovani</i>–Infected Human Macrophages

3 Apr 2007

Abstract excerpt

Visceral leishmaniasis is a protozoal disease caused by the intracellular parasites Leishmania donovani and L. chagasi/infantum, and it is usually deadly if not treated. To date, no vaccine exists for prophylaxis or immunotherapy, nor has it been established which effector mechanisms of the immune system are most instrumental against the parasites. Recent reports have suggested that CD8(+) T cells, in addition to...

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PMID: 17397010
DOI: 10.1086/513439

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