Article
Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo.
Nature neuroscience - 1 May 2007
Zhong Jian, Li Xiaoyan, McNamee Cara, Chen Adele P, Baccarini Manuela, Snider William D
Abstract excerpt
To define the role of the Raf serine/threonine kinases in nervous system development, we conditionally targeted B-Raf and C-Raf, two of the three known mammalian Raf homologs, using a mouse line expressing Cre recombinase driven by a nestin promoter. Targeting of B-Raf, but not C-Raf, markedly attenuated baseline phosphorylation of Erk in neural tissues and led to growth retardation. Conditional elimination of...
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