Article
Role of excision repair in UVB-induced depletion and recovery of human epidermal Langerhans cells.
Archives of dermatology - 1 Jan 1992
Jimbo T, Ichihashi M, Mishima Y, Fujiwara Y
Abstract excerpt
Skin exposure to UVB radiation deprives the antigen-presenting function and OKT6 monoclonal antibody-binding characteristics of Langerhans cells. Decrease of Langerhans cell population could be relevant to immune surveillance disturbance in the UV-exposed skin. Patients with xeroderma pigmentosum exhibit a thousandfold higher risk for sunlight-induced skin cancers than patients with normal skin, and also have...
Topics
- Antibodies, Monoclonal
- Antigen-Presenting Cells
- Cell Count
- DNA Damage
- DNA Repair
- Dose-Response Relationship, Radiation
- Genetic Complementation Test
- Humans
- Immunohistochemistry
- Langerhans Cells
- Phenotype