Article
A detailed analysis of 16S ribosomal RNA gene segments for the diagnosis of pathogenic bacteria.
Journal of microbiological methods - 1 May 2007
Chakravorty Soumitesh, Helb Danica, Burday Michele, Connell Nancy, Alland David
Abstract excerpt
Bacterial 16S ribosomal RNA (rRNA) genes contain nine "hypervariable regions" (V1-V9) that demonstrate considerable sequence diversity among different bacteria. Species-specific sequences within a given hypervariable region constitute useful targets for diagnostic assays and other scientific investigations. No single region can differentiate among all bacteria; therefore, systematic studies that compare the...
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