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Telomerase activity, hTERT expression, and phosphorylation are downregulated in CD4<sup>+</sup>T lymphocytes infected with human immunodeficiency virus type 1 (HIV‐1)

26 Mar 2007

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) infection is characterized by a progressive decrease of CD4(+) T cells accompanied by other immune dysfunctions. Telomerase is transiently activated in lymphocytes during activation and is able to compensate for the progressive telomeric loss that occurs at each cell division, contributing to ensure the telomere length necessary for multiple proliferative events. The...

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PMID: 17387751
DOI: 10.1002/jmv.20855

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Telomerase activity, hTERT expression, and phosphorylation are downregulated in CD4<sup>+</sup>T lymphocytes infected with human immunodeficiency virus type 1 (HIV‐1)PMID 17387751Read ↗

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