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Article

A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging.

Journal of neuroscience research - 15 May 2007

Beyer Katrin, Humbert Jordi, Ferrer Anna, Lao José I, Latorre Pilar, Lopez Dolores, Tolosa Eduard, Ferrer Isidro, Ariza Aurelio

Abstract excerpt

alpha-Synuclein, the main component of proteinaceous inclusions in synucleinopathies, is centrally involved in aggregation processes preceding Lewy body formation. Here we describe a new alpha-synuclein gene poly-T polymorphism that is situated upstream to exon 3 and consists of three different alleles. A correlation between poly-T length and expression of alpha-synuclein 126 mRNA, an isoform lacking exon 3, was...

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Identifiers

PMID: 17387688
DOI: 10.1002/jnr.21270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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