Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer drug resistance: the central role of the karyotype.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jan 2000

Duesberg Peter, Li Ruhong, Sachs Rainer, Fabarius Alice, Upender Madhvi B, Hehlmann Ruediger

Abstract excerpt

Current genetic and epigenetic theories of cancer-specific drug resistance do not adequately explain: (i) the karyotypic changes that coincide with resistance, (ii) the high rates at which cancer cells acquire and enhance resistance compared to the rates of conventional mutation, (iii) the wide ranges of resistance such as multidrug resistance, (iv) the frequent occurrence of intrinsic drug resistance. We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Benzamides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catalysis

Share to Chromosome Aberrations

Share to Imatinib Mesylate

Share to Karyotyping

Share to Piperazines

Share to Pyrimidines

Source

Identifiers

PMID: 17387035
DOI: 10.1016/j.drup.2007.02.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer drug resistance: the central role of the karyotype.PMID 17387035Read ↗

Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapiesSemantic proximity Read ↗

Genomics and Cancer Drug ResistanceSemantic proximity Read ↗

The cellular origins of drug resistance in cancer.Semantic proximity Read ↗

Chromosomal instability and aneuploidy as causes of cancer drug resistanceSemantic proximity Read ↗

Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy.Semantic proximity Read ↗

Genetic and non‐genetic drug resistance: Darwin or Lamarck?Semantic proximity Read ↗

The chromosomal basis of cancer.Semantic proximity Read ↗

Tracking Karyotype Changes in Treatment-Induced Drug-Resistant Evolution.Semantic proximity Read ↗

Multiple paths to a drug resistance phenotype: mutations, translocations, deletions and amplification of coding genes or promoter regions, epigenetic changes and microRNAs.Semantic proximity Read ↗

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistanceSemantic proximity Read ↗

Non-genetic mechanisms of drug resistance in acute leukemiasSemantic proximity Read ↗

Resistance to chemotherapy: new treatments and novel insights into an old problemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.