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Article

A matched crossover design for clinical trials.

Contemporary clinical trials - 1 Sept 2007

Simon Laura J, Chinchilli Vernon M

Abstract excerpt

Two design principles are used frequently in clinical trials: 1) A subject is "matched" or "paired" with a similar subject to reduce the chance that other variables obscure the primary comparison of interest. 2) A subject serves as his/her own control by "crossing over" from one treatment to another during the course of an experiment. There are situations in which it may be advantageous to use the two design...

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Identifiers

PMID: 17383239
DOI: 10.1016/j.cct.2007.02.003
PMCID: PMC2001189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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