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Article

Delayed Tumor Onset in Transgenic Mice Fed a Low-Folate Diet

4 Mar 1992

Abstract excerpt

BACKGROUND: Transgenic mice carrying the human T-lymphotropic virus type 1 tax1 (transactivator) gene develop peripheral nerve sheath tumors with well-characterized times of onset and tissue involvement. PURPOSE AND METHODS: To evaluate the effect of dietary folic acid on age at tumor onset and on the concentration of folate in tissues and tumors, we bred heterozygous transgenic mice and systematically assigned...

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PMID: 1738184
DOI: 10.1093/jnci/84.5.332

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Source receipt: pubmed, retrieved 7 Sept 2026.

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