Article
GFP-transduced CD34+ and Lin- CD34- hematopoietic stem cells did not adopt a cardiac phenotype in a nonhuman primate model of myocardial infarct.
Experimental hematology - 1 Apr 2007
Norol Francoise, Bonnet Nicolas, Peinnequin Andre, Chretien Fabrice, Legrand Roger, Isnard Richard, Herodin Francis, Baillou Claude, Delache Benoit, Negre Didier, Klatzmann David, Vernant Jean-Paul, Lemoine Francios M
Abstract excerpt
OBJECTIVE: Studies in mice have reported contradictory results on the contribution of bone marrow cells to myocardial regeneration. This study aims to evaluate their ability to differentiate into cells of cardiac lineage in a nonhuman primate mode of myocardial infarct. MATERIALS AND METHODS: Lin(-)CD34(-) and CD34(+)-enriched bone marrow cells or mobilized peripheral blood cells were transduced with green...
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