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Frequent Frameshift and Point Mutations in the SH Gene of Human Metapneumovirus Passaged In Vitro

22 Mar 2007

Abstract excerpt

During the preparation of recombinant derivatives of the CAN97-83 clinical isolate of human metapneumovirus (HMPV), consensus nucleotide sequencing of the recovered RNA genomes provided evidence of frequent sequence heterogeneity at a number of genome positions. This heterogeneity was suggestive of sizable subpopulations containing mutations. An analysis of molecularly cloned cDNAs confirmed the presence of mixed...

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PMID: 17376897
DOI: 10.1128/jvi.00128-07

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