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Article

Recurrent mutations associated with isolation and passage of SARS coronavirus in cells from non-human primates.

Journal of medical virology - 1 Aug 2005

Poon Leo L M, Leung Cynthia S W, Chan Kwok H, Yuen Kwok Y, Guan Yi, Peiris Joseph S M

Abstract excerpt

Four clinical isolates of SARS coronavirus were serially passaged in two primate cell lines (FRhK4 and Vero E6). Viral genetic sequences encoding for structural proteins and open reading frames 6--8 were determined in the original clinical specimen, the initial virus isolate (passage 0) and at passages 5, 10, and 15. After 15 passages, a total of 15 different mutations were identified and 12 of them were...

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Identifiers

PMID: 15977248
DOI: 10.1002/jmv.20379
PMCID: PMC7166449

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