Article
MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae.
American journal of medical genetics. Part A - 1 Feb 2005
Parle-McDermott Anne, Mills James L, Kirke Peadar N, Cox Christopher, Signore Caroline C, Kirke Sandra, Molloy Anne M, O'Leary Valerie B, Pangilinan Faith J, O'Herlihy Colm, Brody Lawrence C, Scott John M
Abstract excerpt
This study examined the relationship between folate/homocysteine-related genetic polymorphisms: MTHFD1 1958G --> A (R653Q), MTHFR 677C --> T (A222V), MTHFR 1298A --> C (E429A), and risk of severe abruptio placentae. We genotyped 62 women with a pregnancy history complicated by severe abruptio placentae and 184 control pregnancies. Analysis of the MTHFD1 1958G --> A (R653Q) polymorphism showed increased frequency...
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