Article
Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype.
Digestion - 1 Jan 2006
Perfumo Chiara, Bonelli Luigina, Menichini Paola, Inga Alberto, Gismondi Viviana, Ciferri Enrico, Percivale Pierluigi, Bianchi Scarrà Giovanna, Nasti Sabina, Fronza Gilberto, Varesco Liliana
Abstract excerpt
BACKGROUND: Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma. AIM: To explore the impact of the p53 PIN3-Arg72Pro haplotype on colorectal adenoma formation and progression to cancer. METHODS: One hundred and eighty-four colorectal tumor...
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