Article
L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition.
International journal of cancer - 15 Jul 2007
Antonescu Cristina R, Busam Klaus J, Francone Todd D, Wong Grace C, Guo Tianhua, Agaram Narasimhan P, Besmer Peter, Jungbluth Achim, Gimbel Mark, Chen Chin-Tung, Veach Darren, Clarkson Bayard D, Paty Philip B, Weiser Martin R
Abstract excerpt
Activating mutations in either BRAF or NRAS are seen in a significant number of malignant melanomas, but their incidence appears to be dependent to ultraviolet light exposure. Thus, BRAF mutations have the highest incidence in non-chronic sun damaged (CSD), and are uncommon in acral, mucosal and CSD melanomas. More recently, activating KIT mutations have been described in rare cases of metastatic melanoma,...
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