Article
TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations.
Brain : a journal of neurology - 1 May 2007
Seelaar Harro, Schelhaas H Jurgen, Azmani Asma, Küsters Benno, Rosso Sonia, Majoor-Krakauer Danielle, de Rijk Maarten C, Rizzu Patrizia, ten Brummelhuis Ming, van Doorn Pieter A, Kamphorst Wouter, Willemsen Rob, van Swieten John C
Abstract excerpt
Frontotemporal dementia is accompanied by motor neuron disease (FTD + MND) in approximately 10% of cases. There is accumulating evidence for a clinicopathological overlap between FTD and MND based on observations of familial aggregation and neuropathological findings of ubiquitin-positive neuronal cytoplasmatic inclusions (NCI) in lower motor neurons, hippocampus and neocortex in both conditions. Several familial...
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