Article
Role of the CDKN1A/p21, CDKN1C/p57, and CDKN2A/p16 genes in the risk of atherosclerosis and myocardial infarction.
Cell cycle (Georgetown, Tex.) - 1 Mar 2007
Rodríguez Isabel, Coto Eliecer, Reguero Julián R, González Pelayo, Andrés Vicente, Lozano Iñigo, Martín María, Alvarez Victoria, Morís César
Abstract excerpt
Atherosclerosis is characterized by excessive proliferation of neointimal leukocytes and vascular smooth muscle cells (VSMCs). In mice, the manipulation of cell cycle inhibitors such as CDKN1B (p27) and CDKN1A (p21) modifies the risk of developing atherosclerosis. In humans, CDKN1A, CDKN1B and CDKN1C (p57) are differentially expressed in normal versus atherosclerotic vessels. A DNA-polymorphism within the CDKN1B...
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