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Article

Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer.

Breast cancer research and treatment - 1 Jan 2008

van der Groep Petra, Hoelzel Michael, Buerger Horst, Joenje Hans, de Winter Johan P, van Diest Paul J

Abstract excerpt

Fanconi anemia (FA) is a recessive disorder associated with progressive pancytopenia, multiple developmental defects, and marked predisposition to malignancies. FA is genetically heterogeneous, comprising at least 12 complementation groups (A-M). Activation of one of the FA proteins (FANCD2) by mono-ubiquitination is an essential step in DNA damage response. As FANCD2 interacts with BRCA1, is expressed in...

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Share to Cell Proliferation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group D2 Protein

Share to Genes, BRCA1

Share to Immunohistochemistry

Share to Ki-67 Antigen

Share to Microscopy, Fluorescence

Share to Oligonucleotide Array Sequence Analysis

Source

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Identifiers

PMID: 17333336
DOI: 10.1007/s10549-007-9534-7
PMCID: PMC2096638

Genes

FANCD2
BRCA1

Provenance

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Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer.PMID 17333336Read ↗

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