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Article

eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?

Schizophrenia bulletin - 1 Nov 2007

Carter Christopher J

Abstract excerpt

Bipolar disorder and schizophrenia share common chromosomal susceptibility loci and many risk-promoting genes. Oligodendrocyte cell loss and hypomyelination are common to both diseases. A number of environmental risk factors including famine, viral infection, and prenatal or childhood stress may...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17329232
DOI: 10.1093/schbul/sbm007
PMCID: PMC2779884

Genes

AKT1
BDNF
DAO
DAOA
DISC1
DPYSL2
DTNBP1
GRIN1
GRM3
GRM4
IMPA2
MTHFR
NCAM1
NDUFV2
NOS1
NRG1
PDLIM5
RGS4
TNF
XBP1
YWHAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17329232-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?PMID 17329232Read ↗

Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: implications for oligodendrocyte viability.Semantic proximity Read ↗

eIF2B localisation and its regulation during the integrated stress response is cell type specificSemantic proximity Read ↗

Vanishing White Matter Disease Expression of Truncated EIF2B5 Activates Induced Stress ResponseSemantic proximity Read ↗

Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response.Semantic proximity Read ↗

Developmental splicing deregulation in leukodystrophies related to EIF2B mutations.Semantic proximity Read ↗

Vanishing white matter: a leukodystrophy due to astrocytic dysfunction.Semantic proximity Read ↗

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and DiseaseSemantic proximity Read ↗

Mitochondria, oligodendrocytes and inflammation in bipolar disorder: Evidence from transcriptome studies points to intriguing parallels with multiple sclerosisSemantic proximity Read ↗

The Translational Landscape of Reactive Astrocytes Reveals the Impact of eIF2B-mediated Dysregulation in VWM DiseaseSemantic proximity Read ↗

EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.Semantic proximity Read ↗

Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability.Semantic proximity Read ↗

Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro.Semantic proximity Read ↗

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