Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR.

doi:10.1016/j.cca.2007.01.021

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Article

Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR.

Clinica chimica acta; international journal of clinical chemistry - 1 May 2007

Bhattacharyya Sumit, Look Dwight, Tobacman Joanne K

Abstract excerpt

BACKGROUND: The genetic disorder cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, impairing its function as a regulated anion channel involved with fluid secretion across epithelial cells. However, the clinical manifestations of CF are not thoroughly explained by impaired CFTR function. Experimental data have demonstrated oversulfation of...

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