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Article

Genetic analysis of a new mutation conferring cysteine auxotrophy in Saccharomyces cerevisiae: updating of the sulfur metabolism pathway.

Genetics - 1 Jan 1992

Cherest H, Surdin-Kerjan Y

Abstract excerpt

We have identified a mutation in a gene of Saccharomyces cerevisiae, STR1, that leads to a strict nutritional requirement for cysteine. The str1-1 mutation decreases to an undetectable level the cystathionine gamma-lyase activity. This enzyme catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine. The...

Topics

Acetyltransferases
Cystathionine gamma-Lyase
Cysteine
Gene Conversion
Genes, Fungal
Mutation
Phenotype
Saccharomyces cerevisiae
Serine O-Acetyltransferase
Sulfur

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Identifiers

PMID: 1732168
DOI: 10.1093/genetics/130.1.51
PMCID: PMC1204804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1732168-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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