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Article

Genetic analysis of a new mutation conferring cysteine auxotrophy in Saccharomyces cerevisiae: updating of the sulfur metabolism pathway.

Genetics - 1 Jan 1992

Cherest H, Surdin-Kerjan Y

Abstract excerpt

We have identified a mutation in a gene of Saccharomyces cerevisiae, STR1, that leads to a strict nutritional requirement for cysteine. The str1-1 mutation decreases to an undetectable level the cystathionine gamma-lyase activity. This enzyme catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine. The...

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Identifiers

PMID: 1732168
DOI: 10.1093/genetics/130.1.51
PMCID: PMC1204804

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