Article
Mutations in fusA associated with posttherapy fusidic acid resistance in Clostridium difficile.
Antimicrobial agents and chemotherapy - 1 May 2007
Norén T, Akerlund T, Wullt M, Burman L G, Unemo M
Abstract excerpt
In silico, we identified fusA (2,067 bp) in Clostridium difficile 630. Sequencing of fusA in posttherapy fusidic acid-resistant C. difficile isolates from 12 patients with C. difficile-associated diarrhea (CDAD) identified fusA mutations, one or two nonsynonymous substitutions, or in one case a deletion of one codon associated with resistance. Five of these mutations have previously been described in fusA of...
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