Conformational response to ligand binding in phosphomannomutase2: insights into inborn glycosylation disorder.

Abstract excerpt

The most common glycosylation disorder is caused by mutations in the gene encoding phosphomannomutase2, producing a disease still without a cure. Phosphomannomutase2, a homodimer in which each chain is composed of two domains, requires a bisphosphate sugar (either mannose or glucose) as activator, opening a possible drug design path for therapeutic purposes. The crystal structure of human phosphomannomutase2,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Glucose-6-Phosphate
• Share to Glycosylation