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Article

Structure of the multidrug ABC transporter Sav1866 from <i>Staphylococcus aureus</i> in complex with AMP‐PNP

7 Feb 2007

Abstract excerpt

Staphylococcus aureus Sav1866 is a bacterial homolog of the human ABC transporter Mdr1 that causes multidrug resistance in cancer cells. We report the crystal structure of Sav1866 in complex with adenosine-5'-(beta,gamma-imido)triphosphate (AMP-PNP) at 3.4A resolution and compare it with the previously determined structure of Sav1866 with bound ADP. Besides differences in the ATP-binding sites, no significant...

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Identifiers

PMID: 17303126
DOI: 10.1016/j.febslet.2007.01.073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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