Article
Structural determinants of Cys2His2 zinc fingers.
FEBS letters - 13 Jan 1992
Mortishire-Smith R J, Lee M S, Bolinger L, Wright P E
Abstract excerpt
Two mutants of the zinc finger peptide Xfin-31 (Ac-YKCGLCERSFVEKSALSRHQRVHKN-CONH2) containing alterations to the conserved hydrophobic core have been constructed and their zinc-bound structures investigated by 1H NMR techniques. In the first (Xfin-31B) a double mutation R8F/F10G places the conse...
Topics
- Amino Acid Sequence
- Cysteine
- DNA-Binding Proteins
- Histidine
- Magnetic Resonance Spectroscopy
- Molecular Sequence Data
- Mutation
- Peptides
- Protein Conformation
- Recombinant Proteins
- Zinc Fingers